Von Willebrand Disease – First Stage of Hemab Therapeutics’ Trial Completed and New Patients Invited to Enrol

Richmond has completed dosing the first cohort of patients in Velora Pioneer, a phase 1/2 clinical trial investigating Hemab Therapeutics’ HMB-002 as a potential first-in-class subcutaneous therapy for von Willebrand disease (VWD). Richmond is now actively recruiting people with VWD for subsequent cohorts in Velora Pioneer.  

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Von Willebrand disease is the most common inherited bleeding disorder, with bleeding episodes that can range from frequent, low volume bleeds that impact daily living to potentially life-threatening events. Current treatment options for VWD primarily focus on reactively managing symptoms rather than addressing the underlying condition proactively.

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HMB-002 is a monovalent antibody uniquely designed to increase levels of von Willebrand Factor (VWF) and Factor VIII. It is hoped that HMB-002 will provide a long-acting, subcutaneous prophylactic treatment for individuals with VWD, potentially transforming the standard of care for this condition.

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Principal Investigator, Richmond’s Dr. Ulrike Lorch said: “Von Willebrand is a disease which affects over 12,000 people in the UK. We are delighted to be involved in a trial which may offer hope, not just for future generations of patients, but for those currently experiencing the day-to-day impacts of this often-debilitating condition.”

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How to Participate

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If you have VWD and are interested in participating, please visit Trials4Us where a representative from Richmond Pharmacology will contact you with more information.

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More information about this trial can be found here.

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Additional details about the Hemab Therapeutics clinical program for HMB-002 are available in the company’s official press release.