NIHR CRN video in which patients and network staff talk about their experiences of being involved in clinical research
Publications
Richmond Pharmacology is committed to publishing data from clinical trials, however, we will only do so
in agreement with our clients or where we own the intellectual property. This page provides access to
a selection of publications grouped by the area of research.
Our latest scientific posters and presentations
are featured at the end of each section.
If you would you like us to send you the full article please click here.
Cardiac Safety
Insulin at normal physiological levels does not prolong QTc interval in thorough QT studies performed in healthy volunteers. Taubel et al. Br J Clin Pharmacol 2012;75(2): 392–403
Repeated supratherapeutic dosing of strontium ranelate over 15 days does not prolong QTc interval in healthy volunteers. Taubel et al. Br J Clin Pharmacol 2012;74(2): 296–303
Comparison of the effects of levofloxacin on QT/QTc interval assessed in both healthy Japanese and Caucasian subjects. Sugiyama et al. Br J Clin Pharmacol 2011;73(3): 455-459
Shortening of the QT Interval After Food Can Be Used to Demonstrate Assay Sensitivity in Thorough QT Studies. Taubel et al. J Clin Pharmacol published online 8 November 2011. DOI: 10.1177/0091270011419851
Comparison of Six Commonly Used QT Correction Models and Their Parameter
Estimation Methods. Wang et al. Journal of Biopharmaceutical Statistics
2012; 22(6):1148-1161
Bupivacaine Extended Release Liposome Injection Does Not Prolong QTc Interval in a Thorough QT/QTc Study in Healthy Volunteers. Naseem et al. J Clin Pharmacol published online 4 November 2011. DOI: 10.1177/0091270011419853
The Impact of Insulin Levels on QTc Interval in Thorough QT Studies Conducted in Healthy Subjects. Taubel et al. ACCP Annual Meeting, San Diego 23-25
September
2012
Late Changes After a Euglycaemic Insulin Clamp Can Lead to Significant Increases in QTcF In Healthy Subjects. Taubel et al. 2012 ACCP Annual Meeting, San Diego 23-25
September
2012
Comparison of digital 12-lead ECG and digital 12-lead holter ECG recordings in health male subjects. 112th ASCPT Annual Meeting, March 2-5, 2011, Dallas, TX. Poster Number: PI-08, scheduled on 3/3/2011 from 8:00 AM.
Moxifloxacin effect on QTc interval in the fed and fasted states in Thorough QT studies. Jorg Taubel MD FFPM. DIA/FDA Cardiovascular Safety in Drug Development: State-of-the-art Assessments, Washington 18th April 2012
Clinical Pharmacology and Adaptive Early Phase Studies
Ascending single-dose study with ACT-280778, a non-dihydropyridine, dual L- and T-type calcium channel blocker: safety, tolerability, pharmacokinetics, and effect of food in healthy male subjects. Mueller MS et al. Presented at the American Society for Clinical Pharmacology and Therapeutics Annual Meeting, 5–9 March 2013, Indianapolis, Indiana, USA
The practical application of adaptive study design in early phase clinical trials: a retrospective analysis of time savings. Lorch et al. Eur J Clin Pharmacol (2012) 68:543–551
A phase I, randomised single center, open-label parallel
group trial to compare the pharmacokinetics of NOMAC between healthy female
adolescents (aged 14-17 years) and healthy female adults (aged 18-50 years)
after single dose administration of NOMAC-E2 tablets. This study
included a total of 30 subjects (15 subjects, aged 14-17 subjects, aged 18-50
years), lasting approximately 7 weeks and was the first ever paediatric study
in healthy adolescents to be conducted in Europe.
Rule Britannia – the advantages of conducting first-time-in-human (FTIH) studies in the UK compared to other European markets. Taubel J, Berelowitz K, Lorch U. International Clinical Trials P16+ February 2011
Effects on 24-Hour Intragastric pH: A Comparison of Lansoprazole Administered Nasogastrically in Apple Juice and Pantoprazole Administered Intravenously. Freston J et al. The American Journal of Gastroenterology Vol. 96, No. 7, 2001
Pharmacokinetics, pharmacodynamics and safety of a human anti-IL-6 monoclonal antibody (sirukumab) in healthy subjects in a first-inhuman study Zhenhua Xu et al. Br J Clin Pharmacol 2011 72(2) / 270-281
PET500 A Newly Formulated Tetracaine Product is Effective in Reducing Penile Sensitivity. Taube et al. Thirty-Ninth Annual Meeting American College of Clinical Pharmacology September 12-14, 2010 Baltimore, Maryland. J Clin Pharmacol, September 2010; vol. 50, 9: pp. 1058-1095.
Gastric Acid Suppression Effect of TAK-438, A Potassium-Competitive
Acid Blocker Following Ascending Single Doses in Healthy Subjects. Sakurai et al. 20th United European Gastroenterology Week, Amsterdam,
The Netherlands, 20-24 Oct 2012. GUT 2012: 61 S3: A201
Gastric Acid Suppression Effect of TAK-438, A Potassium-Competitive Acid Blocker Following Ascending Multiple Doses in Healthy Subjects. Jenkins et al. 20th United European Gastroenterology Week, Amsterdam, The Netherlands, 20-24 Oct 2012. GUT 2012: 61 S3: A201
The safety, tolerability and pharmacokinetics of AZD5069, a novel CXCR2 antagonist,in healthy Japanese volunteers. Lorch et al. ERS 2012, September 1 –5, Vienna, Austria
Early Phase Japanese Bridging Studies; Their Global Significance and What to Look for when Selecting a Suitable Contract Research Organisation to Conduct these Studies. Berelowitz K et al. International Pharmaceutical Industry; Volume 3, Issue 1: Page
64-72
Pharmacokinetics and tolerability of sublingual fentanyl in healthy Japanese and Caucasian volunteers: Phase I, open-label, single-dose study. Lorch U et al.
Similar Rivastigmine Pharmacokinetics and Pharmacodynamics in Japanese and White Healthy Participants Following the Application of Novel Rivastigmine Patch. Lefèvre et al. J Clin Pharmacol April 2009 49: 430-443
Pharmacodynamic Consequences of Administration of VLA-4 Antagonist CDP323 to Multiple Sclerosis Subjects: A Randomized, Double-Blind Phase 1/2 Study. Wolf et al. PLOS ONE Journal. March 2013 | Volume 8 | Issue 3 | e58438
Benefits of a Single Versus Multicenter Approach in Early-Phase Patient Studies; A Case Study of Multiple Sclerosis Patients. Berelowitz et al. The Monitor Page 21-25. October 2011
An open-label, parallel-group, repeat-dose study to investigate the effects of end-stage renal disease and haemodialysis on the pharmacokinetics of ropinirole. Tompson et al. 13th International Congress of Parkinson’s Disease and Movement Disorders, Paris, France, June 7–11, 2009
Effect of oseltamivir treatment on anticoagulation: a cross-over study in warfarinized patients. Davies B et al. Br J Clin Pharmacol 2010;70(6):834-843. Single centre drug interaction study in 20 patient volunteers on regular warfarin. The study was performed at Richmond Pharmacology, a further publication describing the recruitment efforts involved has been submitted.
Each month Richmond Pharmacology will give away two copies of the publication, Clinical Trials A Practical Guide to Design, Analysis, and Reporting. Simply fill out the form "Challenge Richmond Pharmacology" and express your interest in receiving a copy from the drop down list and you will be entered into the draw to receive your free copy of this publication.
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